PUBH6005: Epidemiology Assessment 3: Critical Appraisal

ASSESSMENT BRIEF
Subject Code and Title PUBH6005: Epidemiology
Toll Toll 3: Censorious Appraisal
Individual/Group Individual
Acquirements Tidingsinations This toll orationes the subjoined acquirements tidingsinations:
1. Assess levels of averment and coercionm recommendations
2. Interpret basis arising from surveillance and elimination studies, including rates and ratios
3. Understand the variety unordered denomination and causation, statistical and open vigor significance
4. Censoriously evaluate epidemiological studies, including immanent coercion disadvantage, confounding and casualty errors
Submission Imputable Sunday subjoined the purpose of week 11 at
11:55pm AEST/AEDT*
Weighting 40%
Total Marks 100 marks
*Please Advertable attribuconsideration attributablee: This tidings is Sydney tidings (AEST or AEDT). Please appropriate to your admit tidings zindividual (eg. Adelaide = 11:25pm).
PUBH6005_Toll Brief 3 Pgeneration 1 of 8
Context:
This toll requires you to devote the advertable attribuconsideration attributableice and skills gained in whole the modules to embark a censorious appraisal. You succeed scarcity to value 3 creed of a theme and elimination inquiry loving to you by your facilitator.
1. Search the library basisbase to invent three studies that counterpart your elimination inquiry. Whole three studies must be of divergent con-over plans. Coercion occurrence, you could conceive subject restrain, cohort and RCTs. These studies do advertable attribuconsideration attribuconsideration attribuconsideration own to make-trial-of their supposition or consent with each other. Please advertable attribuconsideration attributablee that marks succeed be deducted if whole committerized papers are of concordant con-over.
2. Censoriously value whole three creed you plant. Your counterparts are to be written in the considerations supposing to you which was grounded on CASP checklist and other types of checklist.
3. In the consideration, you are required to counterpart either “Yes”, “No”, “Unclear”.
4. Coercion each of the counterpart of “Yes”, “No” or “Unclear”, you succeed scarcity to supply the “Evidence” that you plant in the word to besidetress your counterparts.
5. Coercion each of the “Evidence”, you succeed scarcity to censoriously value stating your maintenance, assimilate and contrasting or/and providing resolution. Please distinguish consideration coercion an pattern of how “evidence” is written.
References: The attribute of advertences explanationd is great. “lofty attribute advertence” is determined as creed which are peer-reviewed and published in advertable attribuconsideration attributableable interpolitical and national journals. Creed such as innovatingspaper, websites, collective media statements, unsolicited creed and non-peer reviewed creed are advertable attribuconsideration attribuconsideration attribuconsideration of “lofty attribute advertence”. You shwhole Conceive whole the sources you own explanationd amid your quotation and shape them in alphabetical prescribe according to APA 6th edition name. Please distinguish pattern of the attribute and the name of advertencing.
Consideration 3 Cohort con-over: The prophetic and sign stoppage of vascular purposeothelial enlargement element and pentraxin-3 in austere dengue (Low et al., 2018)
Censorious appraisal inquirys Underline your counterpart
Did the con-over oration a explicitly focused result? Yes/No/Unclear
Evidence: maintenance, assimilate and contrasting or/and providing resolution
The external of this con-over was to evaluate VEGF and PTX-3 as prophetic and sign markers in divergentiating austere dengue from non-austere dengue. The external is local to evaluating the couple biomarkers unordered so abundant markers mentioned in the lead con-over that was inaugurateed anteriorly this con-over. (Low, Gan, & Ho, 2015) The dengue genus (austere and non-severe) was validated, local and meteable. It was extraneous from the World Vigor Organisation dengue guideline. (World Vigor Organization, 2009) The con-over besides localally evaluated the prophetic and sign stoppage of the couple markers.
Censorious appraisal inquirys Underline your counterpart
Was the cohort recruited in an accepconsideration Yes/No/Unclear practice?
Evidence: maintenance, assimilate and contrasting or/and providing resolution
The participants were recruited prospectively grounded on the eligibility criteria. Whole participants who are 15 years or older, presented merely in the primitive 3 days of malady and a express NS1 Ag cupel. However, it was unclear of the limitation of the “illness” as it can illustrate a local onset of a symptoms or whether it is imputable to flush. Majority of the strong studies determined the malady commence when resigned patent clear flush. (Ahmed, 2010; Kumar, Gittens-St Hilaire, & Nielsen, 2013; Mahboob et al., 2010) Grounded on Consideration 1, we can take that whole resigneds were recruited grounded on the flush presented amid the primitive 3 days of malady. Suggestion to the committer is to explicitly determine what is “illness”.
NS1 Ag is a mete sign cupel beside anew, most other studies explanationd Dengue IgM as fixatory course. (Mahboob et al., 2010; Tang et al., 2015; Thein et al., 2014) However, the committer justified that Dengue IgM and a over extremely respectful RT-PCR was explanationd to wrap fix the NS1 Ag express subjects.
Censorious appraisal inquirys Underline your counterpart Was the scylla respectfully meted to Yes/No/Unclear minimise disadvantage?
Evidence: maintenance, assimilate and contrasting or/and providing resolution
This con-over did advertable attribuconsideration attribuconsideration attribuconsideration mete any scylla (environmental, collective determinants, anticipation).
Perhaps, the scylla in this con-over was advertable attribuconsideration attribuconsideration attribuconsideration the external in assessing the biomarkers. The
“exposure” here coercion this cohort con-over should be determined as the biomarkers itself. Thus, the
“exposure” is considered respectfully meted by the laboratory technique determined as
ELISA. (Dussart et al., 2008)
Censorious appraisal inquirys Underline your counterpart Was the tidingsination respectfully meted to Yes/No/Unclear minimise disadvantage?
PUBH6005_Toll Brief 3 Pgeneration 3 of 8
Evidence: maintenance, assimilate and contrasting or/and providing resolution
The tidingsination was the explanation of clinical dengue genus (World Vigor Organization, 2012). It was explanationd by the clinician/treating physician to diagnose the resigneds recruited. The stoppage of the WHO clinical genus is well-mannered-mannered documented in other con-over citing that the “austere dengue” kind has amiable sensitivity and locality. (Alexander et al., 2011)
Censorious appraisal inquirys Underline your counterpart
Own the committers committerized whole great confounding elements? Yes/No/Unclear
Evidence: maintenance, assimilate and contrasting or/and providing resolution
Confounding elements such as generation, sex and ethnicity own been committerized. There were other confounding elements such pregnancy; resigned with autoimmune empiricism, haematological empiricism, cancer, cardiovascular ailment or on desire tidings warfarin and aspirin. These were committerized and it was embracing from the separation. The divergent days of malady could besides concern the biomarker results and thus, this confounding element has been conceived into the statistical separation.
Censorious appraisal inquirys Underline your counterpart
Own they taken totality of the confounding elements in the plan and/or separation? Yes/No/Unclear
Evidence: maintenance, assimilate and contrasting or/and providing resolution
Confounding elements own been restrainled coercion by disqualification (detested separation) and conceived into the multivariate retrogression separation.
However, feasible confounding element that the committer has advertable attribuconsideration attribuconsideration attribuconsideration taken into totality was the composition result. No separation on the composition in respects to the biomarker presage. Perhaps, coercionthcoming con-over to evaluate these biomarkers must conceive the types of composition. Composition coercion dengue are largely melting possession and it should be advertable attribuconsideration attributableed dadmit on the divergent commmerely explanationd meltings coercion possession in dengue. (World Vigor Organization, 2012)
Censorious appraisal inquirys Underline your counterpart
Was the supervene up of subjects entire abundance? Yes/No/Unclear
Evidence: maintenance, assimilate and contrasting or/and providing resolution
The supervene up of the subjects were up to the day of acquit from the hospital or vigor heed pliancy. This should content as the resigned recovered and at-liberty of the symptoms or entanglement of the ailment. Other studies did advertable attribuconsideration attribuconsideration attribuconsideration own desire supervene-up, instead they explanationd cross-sectional con-over as their con-over plan. This could perchance imputable to the availability of media to besidetress the desire tidings supervene-up. (Colbert et al., 2007; Mairuhu et al., 2005;
Thein et al., 2014)
Censorious appraisal inquirys Underline your counterpart
Was the supervene up of subjects desire abundance? Yes/No/Unclear
Evidence: maintenance, assimilate and contrasting or/and providing resolution
The supervene up of the subjects were up to the day of acquit from the hospital or vigor heed pliancy. It was the culmination protraction of the resigneds can be supervene-up. Though some resigneds authority enlarge another fact of dengue knadmit as unimportant dengue, this con-over has orationed their external. It succeed be animated to own coercionthcoming con-over that besides supervene-up flush desireer duration of tidings to establish sequelae and unimportant which is over base in dengue purposeemic countries/ typical countries. (Guzmán et al., 2002; Ludolfs, Schilling, Altenschmidt, & Schmitz, 2002) However, this depends on the media serviceable to inaugurate such desire-tidings con-over.
Add joined pages if scarcityed Advertence:
Ahmed, M. M. (2010). Clinical coercionm of dengue flush contagion in King Abdul Aziz University Hospital Saudi Arabia. The Journal of Contagion in Enlargeing Countries, 4(8).
Alexander, N., Balmaseda, A., Coelho, I. C. B., Dimaano, E., Hien, T. T., Hung, N. T., … on interest of the European Union, W. H. O. (WHO-T. besidetressed D. S. G. (2011). Multicentre prospective con-over on dengue genus in disgusting South-east Asian and three Latin American countries. Typical Medicine &
Interpolitical Vigor, 16(8), 936–948. http://doi.org/10.1111/j.1365-3156.2011.02793.x
Colbert, J. A., Gordon, A., Roxelin, R., Silva, S., Silva, J., Rocha, C., & Harris, E. (2007). Ultrasound metement of gallbladder wwhole densification as a sign cupel and signal indicator coercion austere dengue in pediatric resigneds. The Pediatric Infectious Ailment Journal, 26(9), 850–852. Retrieved from
http://journals.lww.com/pidj/Fulltext/2007/09000/ULTRASOUND_MEASUREMENT_OF_GALLBLADD ER_WALL.18.aspx
Dussart, P., Petit, L., Labeau, B., Bremand, L., Leduc, A., Moua, D., … Baril, L. (2008). Evaluation of couple innovating interchangeable cupels coercion the distinction of clever dengue bane contagion using NS1 antigen counteraction in anthropological serum. PLoS Neglected Typical Ailments, 2(8), e280. http://doi.org/10.1371/journal.pntd.0000280
Guzmán, M. G., Kourí, G., Valdés, L., Bravo, J., Vázquez, S., & Halstead, S. B. (2002). Enhanced severity of unimportant dengue-2 contagions: exit rates in 1981 and 1997 Cuban outbreaks. Revista Panamericana de
Salud Pública, 11(4), 223–227. http://doi.org/10.1590/S1020-49892002000400003
Kumar, A., Gittens-St Hilaire, M., & Nielsen, A. L. (2013). Epidemiological trends and clinical manifestations of dengue unordered end in individual of the English-speaking Caribbean countries. Transactions of The Royal Society of Typical Medicine and Hygiene, trt007.
Low, G. K. K., Gan, S.-C., Zainal, N., Naidu, K. D., Amin-Nordin, S., Khoo, C.-S., … Hatta, N. M. (2018). The prophetic and sign stoppage of vascular purposeothelial enlargement element and pentraxin-3 in austere dengue.
Pathogens and Global Vigor, 112(6), 334–341. http://doi.org/10.1080/20477724.2018.1516417
Low, G. K. K., Gan, S. C., & Ho, S. C. (2015). Biomarkers in divergentiating clinical dengue subjects: A prospective cohort con-over. Journal of Coastal Life Medicine, 3(12), 967–970.
Ludolfs, D., Schilling, S., Altenschmidt, J., & Schmitz, H. (2002). Serological divergentiation of contagions with dengue bane serotypes 1 to 4 by using recombinant antigens. Journal of Clinical Microbiology, 40(11), 4317–4320. http://doi.org/10.1128/JCM.40.11.4317-4320.2002
Mahboob, A., Iqbal, Z., Javed, R., Taj, A., Munir, A., & Saleemi, M. A. (2010). Clinical characteristics of resigneds with dengue flush: Report of 48 resigneds in 2010. Journal of Ayub Medical College Abbottabad, 22(4), 23– 120. Mairuhu, A. T. A., Peri, G., Setiati, T. E., Hack, C. E., Koraka, P., Soemantri, A., … Mantovani, A. (2005). Elevated plasma levels of the desire pentraxin, pentraxin 3, in austere dengue bane contagions. Journal of Medical Virology, 76(4), 547–552.
Tang, Y.-L., Chiu, C.-Y., Lin, C.-Y., Huang, C.-H., Chen, Y.-H., Destura, R. V, … Wu, H.-C. (2015).
Establishment and similitude of couple divergent sign platforms coercion counteraction of DENV1 NS1 protein.
Interpolitical Journal of Molecular Sciences, 16(11), 27850–64. http://doi.org/10.3390/ijms161126069
Thein, T., Wansaicheong, G., Gan, V., Dimatatac, F., Go, C., Lye, D., & Leo, Y. (2014). Ultrasound and chest Xray in an adult resigned with dengue. In 63rd Annual Meeting of the American Society of Typical Medicine and Hygiene, ASTMH 2013 (p. 91 (5 SUPPL. 1): 321). Innovating Orleans, LA United States.
World Vigor Organization. (2009). Dengue guidelines coercion distinction, composition, stoppage and restrain. (Innovating ed). Geneva, Switzerland: WHO Press.
World Vigor Organization. (2012). Handbook coercion clinical government of dengue. Geneva, Switzerland: WHO Press.
Media coercion this assignment
Critically appraising INDIVIDUAL creed
Rychetnick, L., Frommer, M., Hawe, P., & Shiell, A. (2002). Criteria coercion evaluating averment on open vigor. Journal of Epidemiology and Community Vigor, 56, 119-127.
Young, J.M., & Solomon, M.J. (2009). How to censoriously value an word. Nature Clinical Practice Gastroenterology and Hepatology. 6, 82-91.
CASP UK. Censorious appraisal skills program checklists (2018). Retrieved from http://www.caspuk.net/#!casp-tools- checklists/c18f8
Thinking encircling disadvantage
Skelly, A. C., Dettori J. R., & Brodt, E. K. (2012). Assessing disadvantage: the avail of because confounding. Averment Grounded Spine Heed Journal, 3(1), 9-12
Note: Please advert to the Academic Writing Guide as serviceable in the Academic Skills exception on your Acquirements Portal

PUBH6005 Toll 3 Marking Rubric
Assessment
Attributes Unaccepconsideration Poor Functional Proficient Advanced Exceptional
Censorious Appraisal Checklist, 30 marks
Consideration 1:
Checklist is explanationd to value the con-over with besidetressing averment and censorious appraisal. (30 marks) Fails to counterpart each inquiry and supply besidetressing averment.
Poor censorious appraisal.
0 1 2 3 4 5 Whole inquirys counterparted beside some besidetressing averment. Irapt censorious appraisal.
6 7 8 9 10 Counterparted whole inquirys and besidetressing averment are apt.
Accepconsideration censorious appraisal.
11 12 13 14 15 Counterparted whole inquirys and besidetressing averment are apt with censorious appraisal.
16 17 18 19 20 Counterparted whole inquirys and besidetressing averment are apt with well-mannered
developed, some
primary censorious appraisal.
21 22 23 24 25 Counterparted whole inquirys and broad-range, lofty attribute besidetressing averment with extremely patent clear, primary censorious appraisal.
26 27 28 29 30
Consideration 2:
Checklist is explanationd to value the con-over with besidetressing averment and censorious appraisal. (30 marks)
Fails to counterpart each inquiry and supply besidetressing averment.
Poor censorious appraisal.
0 1 2 3 4 5 Whole inquirys counterparted beside some besidetressing averment. Irapt censorious appraisal.
6 7 8 9 10 Counterparted whole inquirys and besidetressing averment are apt.
Accepconsideration censorious appraisal.
11 12 13 14 15 Counterparted whole inquirys and besidetressing averment are apt with censorious appraisal.
16 17 18 19 20 Counterparted whole inquirys and besidetressing averment are apt with extremely patent clear, some primary censorious appraisal.
21 22 23 24 25 Counterparted whole inquirys and broad-range, lofty attribute besidetressing averment are apt with extremely patent clear, primary censorious appraisal.
26 27 28 29 30
Consideration 3:
Checklist is explanationd to value the con-over with besidetressing averment and censorious appraisal. (30 marks)
Fails to counterpart each inquiry and supply besidetressing averment.
Poor censorious appraisal.
0 1 2 3 4 5 Whole inquirys counterparted beside some besidetressing averment. Irapt censorious appraisal.
6 7 8 9 10 Counterparted whole inquirys and besidetressing averment are apt.
Accepconsideration censorious appraisal.
11 12 13 14 15 Counterparted whole inquirys and besidetressing averment are apt with censorious appraisal.
16 17 18 19 20 Counterparted whole inquirys and besidetressing averment are apt with extremely patent clear, some primary censorious appraisal.
21 22 23 24 25 Counterparted whole inquirys and broad-range, lofty attribute besidetressing averment are apt with extremely patent clear, primary censorious appraisal.
26 27 28 29 30
References
(10 marks)
PUBH6005 Lack of advertencing.
0 0.5 1 1.5 2 2.5
_Toll Brief 4 Insufficient advertencing or/and shameful mistakes in APA 6th Edition name Minimal advertencing or/and some mistakes in APA 6th Adequate advertencing or/and minimal mistakes in No mistakes in APA 6th Edition name and inquotation extract.
7.5 8 8.5 No mistakes in APA 6th Edition name and in-quotation extract.
Pgeneration 7 of 8
and unbefitting in-quotation extract.
3 3.5 4 Edition name and inquotation extract.
4.5 5 5.5 APA 6th Edition name and in-quotation extract.
6 6.5 7 9 9.5 10
PUBH6005_Toll Brief 4 Pgeneration 8 of 8

Author: Julie Green